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DeCS
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Descriptor English:
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GABA Modulators
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Descriptor Spanish:
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moduladores del GABA
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Descriptor Portuguese:
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Moduladores GABAérgicos
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Synonyms English:
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Acid Modulators, gamma-Aminobutyric
GABAergic Modulators
Modulators, GABA
Modulators, GABAergic
Modulators, gamma-Aminobutyric Acid
gamma Aminobutyric Acid Modulators
gamma-Aminobutyric Acid Modulators
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Tree Number:
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D27.505.519.625.240.500
D27.505.696.577.240.500
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Definition English:
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Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. |
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Indexing Annotation English:
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GEN or unspecified; prefer specifics
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See Related English:
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Anesthetics, General
Anti-Anxiety Agents
Hypnotics and Sedatives
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History Note English:
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95
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Allowable Qualifiers English:
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Record Number:
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32238
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Unique Identifier:
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D018757
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Occurrence in VHL:
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Similar:
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DeCS
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